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Thursday, November 5, 2009

Support For Abstinence From Smoking

Posted by Prahallad Panda on 7:38 PM 1 comments

A 'No Smoking' signImage via Wikipedia
Abstinence from smoking, a difficult to achieve affair, has been supported variously by drug treatment. Traditionally, nicotine patch, lozenges and bupropion were being prescribed. I addition to it, smokeless and electronic cigarettes were also given to lessen the damage. But, more often they do not help in quiting smoking. The adverse effects if nicotine and the risks remained unchanged. Now, a new drug varenicline is showing promise in many cases.It's property, as a partial agonist of alpha4beta2 nicotine acetylcholine receptor, helps the patient to get some satisfaction and quiet smoking. There are also side effects of this drug. Please go through the full article in The Medpagetoday.
clipped from www.medpagetoday.com
SAN DIEGO -- Much as it aided the general population of smokers, varenicline (Chantix) helped patients with chronic obstructive pulmonary disease (COPD) quit too, a randomized trial showed.
From weeks nine to 12 of treatment, 42.3% of those taking varenicline remained abstinent, compared with 8.8% of those taking placebo (P<0.001), Donald Tashkin, MD, of the University of California Los Angeles, reported at the American College of Chest Physicians meeting here.
Varenicline and bupropion are the two first-line pharmacologic aids for smoking cessation recommended by the Department of Health and Human Services' Public Health Service in guidelines updated in 2008.
There was one report of aggression in the varenicline group. Reports of anxiety, depression, depressed mood, and depressive symptoms were infrequent and similar in number between the two groups.

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