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Saturday, July 24, 2010

Is Diabetes II Linked to Bone Froming Cells

Posted by Prahallad Panda on 7:58 PM Comments

Bone is broken down by osteoclasts, and rebuil...Image via Wikipedia
I quote from Cell;

"The broad expression of the insulin receptor suggests that the spectrum of insulin function has not been fully described. A cell type expressing this receptor is the osteoblast, a bone-specific cell favoring glucose metabolism through a hormone, osteocalcin, that becomes active once uncarboxylated. We show here that insulin signaling in osteoblasts is necessary for whole-body glucose homeostasis because it increases osteocalcin activity. To achieve this function insulin signaling in osteoblasts takes advantage of the regulation of osteoclastic bone resorption exerted by osteoblasts. Indeed, since bone resorption occurs at a pH acidic enough to decarboxylate proteins, osteoclasts determine the carboxylation status and function of osteocalcin. Accordingly, increasing or decreasing insulin signaling in osteoblasts promotes or hampers glucose metabolism in a bone resorption-dependent manner in mice and humans. Hence, in a feed-forward loop, insulin signals in osteoblasts activate a hormone, osteocalcin, that promotes glucose metabolism."

Insulin glucose metabolism ZP (it)Image via Wikipedia

The bone forming cells may have a role in initiation of the disease diabetes II.

Insulin oscillationsImage via Wikipedia
clipped from

Insulin Signaling in Osteoblasts Integrates Bone Remodeling and Energy Metabolism

  • Insulin signaling in mouse osteoblasts increases activity of the hormone osteocalcin

  • Osteocalcin activation depends on the acidic pH in the bone resorption area

  • Enhanced osteocalcin activity promotes glucose metabolism via bone resorption

  • Regulation of glucose metabolism by bone also occurs in humans

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