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Wednesday, May 4, 2011

Polyphenol from Grapes may be Used for Drug-Eluding Stents

Posted by Prahallad Panda on 7:15 AM Comments

It is said that the consumption of red wine in prescribed amounts may be good for heart due to the polyphenols, resveratrol and quercetin content. Now, researchers say that stents used in angioplasty can be coated with it to produce what is called as drug-eluding stent. These molecules basically act as antioxidants

Those can have several benefits as seen by the researchers from rat model; "red-wine" polyphenol-eluting stent reduced neointimal hyperplasia and promoted reendothelialization in diseased heart arteries after angioplasty.

At present bioresorbable everolimus drug-eluding stents from polylactic acid found in corn, magnetized stents with nanoparticle(iron) containing endothelial cells, platinum-chromium paclitaxel coated drug-eluding stents and conventional stents are available.

The main concern after angioplasty is re-stenosis, thrombus formation and healing problem at the site of injury after angioplasty.

It is seen in the animal models that "red wine" polyphenol eluding stents reduced restenosis, accelerated reendothelialization, and reduced inflammatory cell activation. Earlier studies have also shown that quercetin, also found in wine grapes, is a strong antioxidant that inhibits platelet activation and vascular smooth-muscle-cell proliferation.

Let us expect for a biodegradable drug-eluding stent for better result after a coronary angioplasty.

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