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Tuesday, September 13, 2011

A Muscle and Fat Cell Protein Cardiotrophin 1 Shows Promise in Treatment of Obesity

Posted by Prahallad Panda on 9:07 PM Comments

A muscle and fat cell protein Cardiotrophin 1 shows promise in treatment of obesity and metabolic syndrome. Metabolic syndrome is characterised by:
Cardiotrophin 1 has cell protective effect and effect in tissue regeneration. It was developed for its use in organ transplant.
 Excess adipose tissue around a male's mid-section.Image of Excessive Adipose Tissue in Abdomen
Researchers found that the administration of cardiotrophin 1 accelerates the elimination of fat from the adipose tissue and increases the rate at which fat is burnt in muscles.
Treatment of obese and diabetic mice with cardiotrophin 1;
  • Iincreased energy expenditure,
  • Reduced food intake and 
  • Corrected obesity and diabetes. 
They also noticed that in addition to its effects on fat metabolism, cardiotrophin 1 promotes the entry of glucose into the cells and increases the insulin sensitivity.

Cardiotrophin 1 (CT-1) is a member of the interleukin-6 cytokine family. The use of CT-1 in liver transplantation has already been granted Orphan Drug Status by both the FDA and the EMEA.
Let us watch for new developments in this front.

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