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Saturday, July 12, 2014

Sandalwood Scent Activate Olfactory Receptors in Skin to hasten wound healing

Posted by Prahallad Panda on 9:58 PM Comments



Skin can smell!
Skin cells can get excited by the fragrance from sandal wood and kick start wound healing; the researchers from Ruhr-Universität Bochum, Germany have discovered.

English: Glass vial containing Sandalwood (San...
English: Glass vial containing Sandalwood (Santalum album) Essential Oil (Photo credit: Wikipedia)

Not only nose is the site for Olfactory Receptors (OR) as popularly known, but also these receptors are housed in many other cells; spermatozoa, melanocytes and dendritic cells etc..
They have found several ORs in the skin cells called keratinocytes viz. OR6M1, OR11A1, OR6V1, OR5V1 and OR2AT4 using microarray and RT-PCR analyses.
Out of the host of olfactory receptors, OR2AT4 is of special interest for wound healing because activated OR2AT4 triggers the proliferation and migration of keratinocytes, which are the essential steps for re-epithelialization of the wounds.
Possibly this happens via calcium-dependant signalling pathway in primary keratinocytes induced by Sandalore and Brahmanol found in sandal wood oil.
Further down stream, the signaling cascade possibly activates the cAMP/PKA pathway or multiple pathways including EGFR to the phosphorylation of the MAP kinases Erk1/2 and p38, resulting the increased proliferation and migration of cells.
All the synthetic sandalwood molecules may not have the desired molecules to have the effect.



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