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Friday, June 25, 2010

Nanoparticles as Antibodies

Posted by Prahallad Panda on 9:51 PM Comments

Plastic nanoparticles acted as antibody in capturing the bee venom in mice.

In a 1st, experts create plastic antibodies to fight antigens


Researchers from the University
of California at Irvine who worked on the project along with scientists from
Stanford University and Japan’s University of Shizuoka, created
nanoparticle-size plastic polymers to encase melittin, a toxic peptide in bee
venom that causes cells to rupture. Large quantities of melittin can lead to
organ failure and death.

The nanoparticles succeeded in “capturing” the
antigens before they could disperse, thus reducing deaths among the mice, which
also fared well in the weeks following the jab, according to UCI professor
Kenneth Shea. Mice in a control group injected with the toxin but not the
antibodies did not survive. “Never before have synthetic antibodies been
shown to effectively function in the bloodstream of living animals,” Shea
said. “This technique could be utilized to make plastic nanoparticles
designed to fight more lethal toxins and pathogens.”
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